In 1996, when a polysaccharide isolated from the Cordyceps mycelium was intraperitoneally injected, a research team led by Professor Ukai of the Jipu University of Pharmacy in Japan and Professor Hui of the China University of Pharmacy in China showed hypoglycemic activity in diabetic mice and a rapid decrease in glucose concentration in normal mice. After intraperitoneal injection of Cordyceps Polysaccharide extracts at a concentration of 50 mg/Kg into genetically diabetic mice, the plasma glucose concentration over time was analyzed. As a result, the glucose concentration of diabetic mice within 6 hours of Polysaccharide injection The glucose-lowering effect of Cordyceps was rapidly reduced to the normal mouse glucose concentration, and as time passed, the glucose concentration showed a tendency to return to the diabetic state.
On the other hand, Professor Ukai’s research team showed a tendency to decrease plasma glucose concentration even after oral administration of the extract fraction of Cordyceps, but the blood sugar lowering effect was weaker than that of intraperitoneal injection. reported that galactose, glucose, and mannose were composed of 62:28:10 (molar%) and a molecular weight of about 45,000.
In another experiment, as a result of intraperitoneal injection of Cordyceps Cordyceps extract at a concentration of 50 mg/Kg into normal mice and analyzing plasma triglycerides, the triglyceride-lowering effect appeared within a short time, and the effect gradually disappeared over time. On the other hand, the cholesterol concentration was significantly decreased 3 hours after intraperitoneal injection of Cordyceps polysaccharide extract but was restored to the original state after 6 hours. In other words, the cholesterol-lowering effect was recognized, but the maintenance period was short.
